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Anti-Autoimmune Disorders-Specific Antibody Discovery from Premade Phage Displayed Antibody Library

As a leading antibody discovery service provider, Creative Biolabs has established advanced phage display antibody production platform. With abundant experience and professional scientists, we are confident in offering customized biopanning strategies for both therapeutic monoclonal antibodies and reagent antibodies discovery. Particularly, we are happy to share our expertise to promote the discovery of anti-disease-specific target antibodies, which including but not limited to anti-autoimmune disorders-specific antibodies.

Anti-Autoimmune Disorders-Specific Antibody

Autoimmune diseases are conditions in which immunologic tolerance for specific self-proteins is lost, and the adaptive immune system orchestrates the injury of organs expressing those proteins. Most autoimmune disorders are associated with autoantibodies that are reactive against self-proteins. Generally, complement inhibition has been treated as an effective strategy for blocking multiple pathways of injury common to these diseases. Besides, some biologic pathways have been explored to target various steps of the immune system and various monoclonal antibodies, such as tumor necrosis factor-alpha (TNF-a) inhibitors, interleukins inhibitors, and anti-integrin antibodies, have been developed for the treatment of autoimmune diseases.

Anti-Autoimmune Disorders-Specific Antibody Discovery from Premade Phage Displayed Antibody LibraryFig.1 Antigen-specific therapeutic approaches for autoimmunity. (Pau Serra and Pere Santamaria, 2019)

Premade Phage Displayed Antibody Library Screening for Anti-Autoimmune Disorders-Specific Antibody

Since the development of the hybridoma and humanization technique, several monoclonal antibodies have been approved for the treatment of autoimmune diseases. With rich experience and well-established phage display platform, Creative Biolabs has established plentiful premade phage displayed antibody libraries with large capacity and diversity, which enables us to offer high-quality phage display library screening service against a specific target. Our professional scientists are pleased to select the most appropriate phage display system to meet our customers' demands. Our premade phage displayed antibody libraries include:

Libraries Library ID Display Technology Library Format Species Library Size
Phage display human scFv libraries HuScL-2 Phage Display scFv Human 1.42×109
HuScL-4 Phage Display scFv Human 2.0×109
HuScL-6 Phage Display scFv Human 1.0×1011
HuScL-7 Phage Display scFv Human 1.1×1010
Phage display human Fab libraries HuFabL-4 Phage Display Fab Human 1.9×1010
HuFabL-5 Phage Display Fab Human 1.1×1010
HuFabssL-1 Phage Display Fab Human 1.8×1010


Creative Biolabs also provides antibody discovery services for different types of targets to suit a variety of applications:


Advantages of Our Service


Creative Biolabs offers comprehensive premade antibody library screening services for global customers. Our scientists and expert technicians are dedicated to customizing your program to best tailor your requirements. For more detailed information, please feel free to contact us and our team will get back to you as soon as possible.

Reference

  1. Pau Serra and Pere Santamaria (2019), Engineering therapeutic antibodies to combat infectious diseases. Nature Biotechnology, volume 37, pages238-251.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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