Bifunctional Antibodies Discovery from Premade Phage Displayed Antibody Library

Creative Biolabs possesses enriched experience in premade antibody library screening for various antibodies discovery. In recent years, our scientists are devoted to developing bispecific antibodies (BsAbs) with high controllability and operability. With more than ten years of industry experience, we are happy to help global researchers screen specific bifunctional antibodies from our premade phage displayed antibody library faster and effectively.

Bifunctional Antibodies

Bispecific antibodies, which recognize two different epitopes either on the same or on different antigens, have become increasingly of interest for diagnostic, imaging, prophylaxis, and therapeutic applications. In addition to retargeting of effector molecules, cells and genetic vehicles, therapeutic applications of bispecific antibodies including dual targeting and pretargeting strategies, half-life extension, and delivery through biological barriers such as the blood-brain barrier have been also explored. Particularly, bispecific antibodies have been evaluated as potential treatments for a variety of indications, including cancer, chronic inflammatory diseases, autoimmunity, neurodegeneration, bleeding disorders, and infections.

Bifunctional Antibodies Discovery from Premade Phage Displayed Antibody Library Fig.1 Schematic overview of the different strategies used to generate bispecific antibodies (bsAbs) derived from the antigen-binding sites of two different antibodies. (Kontermann, 2015)

Premade Phage Displayed Antibody Library Screening for Bifunctional Antibodies Discovery

Currently, most BsAbs are generated by three methods: by chemical conjugation with cross-linkers, by somatic fusion of two hybridoma lines (quadroma), and by genetic (protein/cell) engineering. Among these methods, phage display technology has played a key role in the discovery and optimization of antibodies for diverse applications. Phage display library screening has become an effective technique for the enrichment and identification of antibodies with high affinity and specificity for interested targets. With rich experience and advanced technology platform, Creative Biolabs has constructed a full package of premade phage display antibody libraries with large capacity and diversity. Our scientists are confident in offering the best and most comprehensive library screening services to promote the rapid discovery of large numbers of high-potency bifunctional antibodies against the interest targets. The premade phage displayed antibody libraries available in Creative Biolabs are listed as following:

Creative Biolabs also provides antibody discovery services for different types of targets to suit a variety of applications:

Advantages of Our Premade Library Screening Service

Various library resources with large capacity and diversity
Customized study design to satisfy every client's requirements
Screened antibodies are well-compatible to various engineering and modifications
Targets can be provided by clients or synthesized and expressed by our scientists

Based on advanced technology platforms and specialized expertise, Creative Biolabs is dedicated to serving our global clients with high-quality premade phage displayed antibody library screening services. Our scientists are confident in tailoring our customers the most reliable and cost-effective protocol to facilitate their meaningful research. For more detailed information, please feel free to contact us.

Reference

Kontermann, R.E., and Brinkmann, U., 2015. Bispecific antibodies. Drug discovery today, 20(7), pp.838-847.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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