This product is a Farage-Luc2 B cell engineering tool based on the Gold nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-291-SpCas9-Cas9-3'-Azido-3'-deoxythymidine ) genome editor.
| Host Cell | Farage-Luc2 |
| Target | 14-3-3 Pan |
| Insert Clone | BCR76 |
| Safe Harbor Sites (SHS) | SHS-291 |
| gRNA | SpCas9 |
| Nuclease | Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | DOX |
| Particle Size | ≤100 |
| Charge (mv) | 0 to -16 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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