This product is a RPMI 8226 B cell engineering tool based on the Gold nanoparticles (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (AAVS1-tracr RNA-SpCas9-(Z)-4-Hydroxytamoxifen ) genome editor.
| Host Cell | RPMI 8226 |
| Target | ALPP |
| Insert Clone | ALPP/238 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | tracr RNA |
| Nuclease | SpCas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH-dependent |
| Insertion sites | Mouse genome E-6 |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | DOX |
| Particle Size | 10-500 |
| Charge (mv) | 17 to 58 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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