This product is a NAMALWA B cell engineering tool based on the Nanoparticles (Dexamethasone/Glucocorticoid receptor) delivery system and CRISPR-based (huROSA-26-tracr RNA-Cas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | NAMALWA |
| Target | BACE1 |
| Insert Clone | BG-17B |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genomeD-4(2) |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Dexamethasone/Glucocorticoid receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <1000 |
| Charge (mv) | 0 to -31 |
| Total Atom Count | -64000000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Liver cancer; Lung cancer; Colon cancer |
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