This product is a SU-DHL-4 B cell engineering tool based on the Gold nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (SHS-317-sgRNA-Cpf1-3'-Azido-3'-deoxythymidine ) genome editor.
| Host Cell | SU-DHL-4 |
| Target | CCL2 |
| Insert Clone | R6R23 |
| Safe Harbor Sites (SHS) | SHS-317 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 1-100 |
| Charge (mv) | 0 to -30 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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