This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (AAVS1-sgRNA-Cpf1-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CCL2 |
| Insert Clone | R6R28 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH-dependent |
| Insertion sites | Human genome |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <2500 |
| Charge (mv) | 10 to 100 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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