This product is a EB2 [EB-2] B cell engineering tool based on the Solid lipid nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (SHS-289-tracr RNA-Cas9-RS-1 ) genome editor.
| Host Cell | EB2 [EB-2] |
| Target | CD163 |
| Insert Clone | BCXC-2562 |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Regorafenib |
| Particle Size | 10-1000 |
| Charge (mv) | −1 to -20 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Breast cancer; Colon cancer; Glioblastoma; Gastric cancer; Liver cancer |
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