This product is a SU-DHL-4 B cell engineering tool based on the Solid lipid nanoparticles (N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin) delivery system and CRISPR-based (huROSA-26-huIgH296-Cpf1-SCR7 pyrazine) genome editor.
| Host Cell | SU-DHL-4 |
| Target | CD276 |
| Insert Clone | BG-52E |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | huIgH296 |
| Nuclease | Cpf1 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin |
| Active Agents | Thymoquinone |
| Particle Size | 10-1000 |
| Charge (mv) | -2 to -31 |
| Total Atom Count | -57,000,000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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