This product is a Ramos (RA 1) B cell engineering tool based on the Quantum dots (MUC1 aptamer/MUC1) delivery system and CRISPR-based (SHS-323-huIgH296-Cas12-SCR7 pyrazine) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | EphA2 |
| Insert Clone | A3C8CR |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genome E-4 |
| Vehicles | Quantum dots |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | DOX |
| Particle Size | ≤900 |
| Charge (mv) | <-25 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Colon cancer; Lung cancer; Brain cancer; Renal cancer; Leukemia |
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