This product is a GA-10 (Clone 4) B cell engineering tool based on the Magnetic nanoparticles (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (CCR5-SpCas9-NLS-Cas9-Nocodazole) genome editor.
| Host Cell | GA-10 (Clone 4) |
| Target | EphA2 |
| Insert Clone | A3D1CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | Regorafenib |
| Particle Size | 1-100 |
| Charge (mv) | -3 to -71 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Colon cancer; Lung cancer; Brain cancer; Renal cancer; Leukemia |
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