This product is a BC-3 B cell engineering tool based on the Magnetic nanoparticles (Anisamide/ Sigma receptors) delivery system and CRISPR-based (SHS-317-SpCas9-Cas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | BC-3 |
| Target | EphA2 |
| Insert Clone | B6CR74 |
| Safe Harbor Sites (SHS) | SHS-317 |
| gRNA | SpCas9 |
| Nuclease | Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | Anisamide/ Sigma receptors |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <1000 |
| Charge (mv) | -10 to -50 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Colon cancer; Lung cancer; Brain cancer; Renal cancer; Leukemia |
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