This product is a EB2 [EB-2] B cell engineering tool based on the Solid lipid nanoparticles (LRP-1 targeting peptide/Lipoprotein receptor-related protein-1) delivery system and CRISPR-based (SHS-289-huIgH296-Cas12-Nocodazole) genome editor.
| Host Cell | EB2 [EB-2] |
| Target | EphA2 |
| Insert Clone | B6CR70 |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | Nocodazole |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | LRP-1 targeting peptide/Lipoprotein receptor-related protein-1 |
| Active Agents | Celastrol |
| Particle Size | ≤900 |
| Charge (mv) | 17 to 58 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Colon cancer; Lung cancer; Brain cancer; Renal cancer; Leukemia |
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