This product is a ST486 B cell engineering tool based on the Nanoparticles (Transferrin/Transferrin receptor) delivery system and CRISPR-based (SHS-291-huIgH296-Cas12-RS-1) genome editor.
| Host Cell | ST486 |
| Target | EphA2 |
| Insert Clone | D2-1A7CR |
| Safe Harbor Sites (SHS) | SHS-291 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH-dependent |
| Insertion sites | Mouse genome E-6 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Transferrin/Transferrin receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <1660 |
| Charge (mv) | -15 to -185 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Colon cancer; Lung cancer; Brain cancer; Renal cancer; Leukemia |
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