This product is a SU-DHL-10 B cell engineering tool based on the Quantum dots (N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin) delivery system and CRISPR-based (CCR5-tracr RNA-Cas9-Brefeldin A) genome editor.
| Host Cell | SU-DHL-10 |
| Target | ETFB |
| Insert Clone | BCGR-1326CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Quantum dots |
| Ligand/Receptor | N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <500 |
| Charge (mv) | -2 to -30 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Prostate cancer; Breast cancer; Pancreatic cancer; Thyroid carcinoma; Melanoma; Colorectal cancer |
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