This product is a Jiyoye [Jijoye, P-2003, P-3J] B cell engineering tool based on the Solid lipid nanoparticles (LRP-1 targeting peptide/Lipoprotein receptor-related protein-1) delivery system and CRISPR-based (CCR5-SpCas9-NLS-Cas9-Nocodazole) genome editor.
| Host Cell | Jiyoye [Jijoye, P-2003, P-3J] |
| Target | ETFB |
| Insert Clone | BCGR-1328CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH responsive |
| Insertion sites | Mouse genome E-3 |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | LRP-1 targeting peptide/Lipoprotein receptor-related protein-1 |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 10-50 |
| Charge (mv) | 0 to -30 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Prostate cancer; Breast cancer; Pancreatic cancer; Thyroid carcinoma; Melanoma; Colorectal cancer |
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