This product is a RPMI 1788 B cell engineering tool based on the Dendrimers (EGFR mAb/Epidermal Growth Factor Receptor) delivery system and CRISPR-based (SHS-229-tracr RNA-Cas9-RS-1) genome editor.
| Host Cell | RPMI 1788 |
| Target | EZR |
| Insert Clone | B6CR245 |
| Safe Harbor Sites (SHS) | SHS-229 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Dendrimers |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <1000 |
| Charge (mv) | 10 to 30 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Colon cancer; Lung cancer; Ovarian cancer |
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