This product is a HS-Sultan B cell engineering tool based on the Gold nanoparticles (Fucoidan/P-selectin) delivery system and CRISPR-based (CCR5-sgRNA-SpCas9-Brefeldin A) genome editor.
| Host Cell | HS-Sultan |
| Target | EZR |
| Insert Clone | 6F11-E5-F5CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | sgRNA |
| Nuclease | SpCas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH-dependent |
| Insertion sites | Mouse genomeD-4(2) |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Fucoidan/P-selectin |
| Active Agents | Regorafenib |
| Particle Size | ≤900 |
| Charge (mv) | 6 to 86 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Breast cancer; Colon cancer; Lung cancer; Ovarian cancer |
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