This product is a RPMI 8226 B cell engineering tool based on the Nanoparticles (Tumor-homing peptide tLyp-1/NRP-1) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | RPMI 8226 |
| Target | EZR |
| Insert Clone | 48G2CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Tumor-homing peptide tLyp-1/NRP-1 |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 1-100 |
| Charge (mv) | ≤50 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Breast cancer; Colon cancer; Lung cancer; Ovarian cancer |
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