This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (SHS-255-SpCas9-NLS-Cas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FAP |
| Insert Clone | BG-39G |
| Safe Harbor Sites (SHS) | SHS-255 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Bortezomib |
| Particle Size | 20-3000 |
| Charge (mv) | 13 to 67 |
| Total Atom Count | -57,000,000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Breast cancer; Prostate cancer; Lung cancer; Ovarian cancer |
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