This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (huROSA-26-huIgH296-Cpf1-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FAP |
| Insert Clone | BG-38G |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | huIgH296 |
| Nuclease | Cpf1 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | Thymoquinone |
| Particle Size | 10-50 |
| Charge (mv) | 10-93 |
| Total Atom Count | -22,000,000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Breast cancer; Prostate cancer; Lung cancer; Ovarian cancer |
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