This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Anisamide/ Sigma receptors) delivery system and CRISPR-based (hROSA26-sgRNA-Cpf1-L755507) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FEN1 |
| Insert Clone | 1282ABCR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Anisamide/ Sigma receptors |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | ≤900 |
| Charge (mv) | 13 to 65 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Lung cancer |
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