This product is a SKO-007 B cell engineering tool based on the Nanoparticles (Dexamethasone/Glucocorticoid receptor) delivery system and CRISPR-based (CCR5-SpCas9-NLS-Cas9-Nocodazole) genome editor.
| Host Cell | SKO-007 |
| Target | FEN1 |
| Insert Clone | BCG-0492CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Dexamethasone/Glucocorticoid receptor |
| Active Agents | Thymoquinone |
| Particle Size | <500 |
| Charge (mv) | -8 to -55 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Lung cancer |
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