This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (CCR5-crRNA:tracrRNA duplex-Cas12-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FKBP5 |
| Insert Clone | BCG-3347CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | RS-1 |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | Thymoquinone |
| Particle Size | <1660 |
| Charge (mv) | -11 to -445 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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