This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Transferrin/Transferrin receptor) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-SCR7 pyrazine) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FKBP5 |
| Insert Clone | B6CR371 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Transferrin/Transferrin receptor |
| Active Agents | Bortezomib |
| Particle Size | 10-1000 |
| Charge (mv) | -25 to -47 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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