This product is a NAMALWA B cell engineering tool based on the Magnetic nanoparticles (SS-Fc/Carcinoembryonic antigen) delivery system and CRISPR-based (AAVS1-tracr RNA-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | NAMALWA |
| Target | FKBP5 |
| Insert Clone | BCG-0715CR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | SS-Fc/Carcinoembryonic antigen |
| Active Agents | DOX |
| Particle Size | 10-50 |
| Charge (mv) | 0 to -16 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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