This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (SS-Fc/Carcinoembryonic antigen) delivery system and CRISPR-based (CCR5-crispr RNA-SpCas9-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FLT1 |
| Insert Clone | BG-11F |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | SS-Fc/Carcinoembryonic antigen |
| Active Agents | DOX |
| Particle Size | 20-3000 |
| Charge (mv) | ≤50 |
| Total Atom Count | -64,000,000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Colon cancer |
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