This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (EpCAM aptamer/Epithelial cell adhesion molecule) delivery system and CRISPR-based (huROSA-26-SpCas9-NLS-Cas9-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FLT1 |
| Insert Clone | BG-10F |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive |
| Insertion sites | Mouse genome E-6 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | Regorafenib |
| Particle Size | <100 |
| Charge (mv) | 10 to 35 |
| Total Atom Count | -57,000,000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer; Colon cancer |
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