This product is a DS-1 B cell engineering tool based on the Solid lipid nanoparticles (LRP-1 targeting peptide/Lipoprotein receptor-related protein-1) delivery system and CRISPR-based (huROSA-26-crRNA:tracrRNA duplex-Cas12-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | DS-1 |
| Target | FLT1 |
| Insert Clone | BG-6F |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | LRP-1 targeting peptide/Lipoprotein receptor-related protein-1 |
| Active Agents | Bortezomib |
| Particle Size | 10-500 |
| Charge (mv) | ≤50 |
| Total Atom Count | -22,000,000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Colon cancer |
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