This product is a BC-2 B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (CCR5-crRNA:tracrRNA duplex-SpCas9-RS-1) genome editor.
| Host Cell | BC-2 |
| Target | FLT1 |
| Insert Clone | BG-1F |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | SpCas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | DOX |
| Particle Size | <2300 |
| Charge (mv) | 0 to -31 |
| Total Atom Count | -22,000,000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Breast cancer; Lung cancer; Colon cancer |
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