This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-323-SpCas9-NLS-Cas9-3'-Azido-3'-deoxythymidine ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FOLH1 |
| Insert Clone | 4A3 |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH-dependent |
| Insertion sites | Human genome |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | 20-150 |
| Charge (mv) | < 0 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Lung cancer; Brain cancer; Colon cancer; Ovarian cancer; Liver cancer |
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