This product is a Ramos (RA 1) B cell engineering tool based on the Sphingosomes (MUC1 aptamer/MUC1) delivery system and CRISPR-based (SHS-255-SpCas9-NLS-Cas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FOLH1 |
| Insert Clone | BG-21F |
| Safe Harbor Sites (SHS) | SHS-255 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Mouse genome E-5 |
| Vehicles | Sphingosomes |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 20-3000 |
| Charge (mv) | -1 to -20 |
| Total Atom Count | -64,000,000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Lung cancer; Brain cancer; Colon cancer; Ovarian cancer; Liver cancer |
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