This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (EGFR mAb/Epidermal Growth Factor Receptor) delivery system and CRISPR-based (CCR5-tracr RNA-Cas9-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | GPC3 |
| Insert Clone | 7H1 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | Thymoquinone |
| Particle Size | 20-3500 |
| Charge (mv) | 3 to 20 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Breast cancer; Non-small cell lung cancer; Prostate cancer; Liver cancer |
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