This product is a RPMI 8226 B cell engineering tool based on the Nanoparticles (EGFR mAb/Epidermal Growth Factor Receptor) delivery system and CRISPR-based (AAVS1-sgRNA-Cpf1-RS-1 ) genome editor.
| Host Cell | RPMI 8226 |
| Target | GPC3 |
| Insert Clone | M3C11 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Human genome |
| Vehicles | Nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 20-3500 |
| Charge (mv) | 10-90 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Breast cancer; Non-small cell lung cancer; Prostate cancer; Liver cancer |
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