This product is a DS-1 B cell engineering tool based on the Nanoparticles (SS-Fc/Carcinoembryonic antigen) delivery system and CRISPR-based (hROSA26-SpCas9-NLS-Cas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | DS-1 |
| Target | KIR3DL2 |
| Insert Clone | 71L5C71L71L |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH-dependent |
| Insertion sites | Human genome |
| Vehicles | Nanoparticles |
| Ligand/Receptor | SS-Fc/Carcinoembryonic antigen |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | 41-150 |
| Charge (mv) | 13 to 67 |
| Total Atom Count | -55000000 |
| Surface Atoms (%) | -0.7 |
| Specific Surface Area (m2/g) | -3.6 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer |
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