This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (SHS-229-tracr RNA-Cas9-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | KIR3DL2 |
| Insert Clone | chAZ71L58 |
| Safe Harbor Sites (SHS) | SHS-229 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | DOX |
| Particle Size | 22-500 |
| Charge (mv) | ≤71 |
| Total Atom Count | -23000000 |
| Surface Atoms (%) | -4 |
| Specific Surface Area (m2/g) | -7 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Breast cancer; Lung cancer |
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