This product is a MC116 B cell engineering tool based on the Gold nanoparticles (Anisamide/ Sigma receptors) delivery system and CRISPR-based (hROSA26-sgRNA-Cpf1-RS-1) genome editor.
| Host Cell | MC116 |
| Target | SNAI1 |
| Insert Clone | BCGS-2676CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Anisamide/ Sigma receptors |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | <1660 |
| Charge (mv) | 3 to 20 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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