This product is a Pfeiffer B cell engineering tool based on the Magnetic nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (CCR5-crispr RNA-SpCas9-Brefeldin A) genome editor.
| Host Cell | Pfeiffer |
| Target | SNAI1 |
| Insert Clone | BCGS-5991CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Bortezomib |
| Particle Size | 10-50 |
| Charge (mv) | 10 to 55 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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