This product is a SU-DHL-8 B cell engineering tool based on the Microbubbles (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-crRNA:tracrRNA duplex-Cas12-RS-1) genome editor.
| Host Cell | SU-DHL-8 |
| Target | SNAI1 |
| Insert Clone | BCGS-5753CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Microbubbles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | DOX |
| Particle Size | <1000 |
| Charge (mv) | <-25 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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