This product is a GA-10 (Clone 4) B cell engineering tool based on the Magnetic nanoparticles (LRP-1 targeting peptide/Lipoprotein receptor-related protein-1) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | GA-10 (Clone 4) |
| Target | SPN |
| Insert Clone | 4C5-T7 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | LRP-1 targeting peptide/Lipoprotein receptor-related protein-1 |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 22-50 |
| Charge (mv) | −11 to -37 |
| Total Atom Count | -23000000 |
| Surface Atoms (%) | -4 |
| Specific Surface Area (m2/g) | -7 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Colorectal cancer; Lung cancer |
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