This product is a Ramos (RA 1) B cell engineering tool based on the Micelles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (hROSA26-huIgH296-Cas12-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | SPN |
| Insert Clone | 71L5T-2I8 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Micelles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | 41-150 |
| Charge (mv) | ≤71 |
| Total Atom Count | -57000000 |
| Surface Atoms (%) | -0.7 |
| Specific Surface Area (m2/g) | -3.6 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Colorectal cancer; Lung cancer |
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