This product is a SU-DHL-6 B cell engineering tool based on the Nanoparticles (EpCAM aptamer/Epithelial cell adhesion molecule) delivery system and CRISPR-based (AAVS1-SpCas9-NLS-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | SU-DHL-6 |
| Target | SPN |
| Insert Clone | T6X-71LQ Q6XR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Nanoparticles |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | Celastrol |
| Particle Size | <3450 |
| Charge (mv) | < 1 |
| Total Atom Count | -73000000 |
| Surface Atoms (%) | -0.6 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Colorectal cancer; Lung cancer |
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