This product is a RPMI 8226 B cell engineering tool based on the Sphingosomes (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (AAVS1-huIgH296-SpCas9-RS-1) genome editor.
| Host Cell | RPMI 8226 |
| Target | SRSF9 |
| Insert Clone | BCGS-5186CR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Sphingosomes |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <1000 |
| Charge (mv) | -30 to -200 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Ovarian cancer; Non-small-cell lung cancer; Liver cancer |
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