This product is a GA-10 B cell engineering tool based on the Gold nanoparticles (EpCAM aptamer/Epithelial celladhesion molecule) delivery system and CRISPR-based (CCR5-SpCas9-NLS-Cas9-Nocodazole) genome editor.
| Host Cell | GA-10 |
| Target | SRSF9 |
| Insert Clone | BCGS-5886CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH-dependent |
| Insertion sites | Mouse genome E-3 |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | Regorafenib |
| Particle Size | <1660 |
| Charge (mv) | -25 to -125 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Ovarian cancer; Non-small-cell lung cancer; Liver cancer |
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