This product is a Ramos (RA 1) B cell engineering tool based on the Quantum dots (EGFR mAb/Epidermal GrowthFactor Receptor) delivery system and CRISPR-based (hROSA26-huIgH296-Cpf1-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | SRSF9 |
| Insert Clone | BCGS-5724CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | huIgH296 |
| Nuclease | Cpf1 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Quantum dots |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <1660 |
| Charge (mv) | 0 to -30 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Ovarian cancer; Non-small-cell lung cancer; Liver cancer |
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