This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Fucoidan/P-selectin) delivery system and CRISPR-based (SHS-323-huIgH296-NLS-Cas9-L755507) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | SSB |
| Insert Clone | B6CR520 |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | huIgH296 |
| Nuclease | NLS-Cas9 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive |
| Insertion sites | Human genome |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Fucoidan/P-selectin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | ≤900 |
| Charge (mv) | -25 to -125 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Breast cancer; Colon cancer; Glioblastoma; Gastric cancer; Liver cancer |
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