This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Tumor-homing peptide tLyp-1/NRP-1) delivery system and CRISPR-based (SHS-227-sgRNA-Cas9-Nocodazole) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | Thomsen-Friedenreich |
| Insert Clone | BGC78 |
| Safe Harbor Sites (SHS) | SHS-227 |
| gRNA | sgRNA |
| Nuclease | Cas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Tumor-homing peptide tLyp-1/NRP-1 |
| Active Agents | Paclitaxel, chlorin e6 |
| Particle Size | 22-50 |
| Charge (mv) | −1 to -21 |
| Total Atom Count | -23000000 |
| Surface Atoms (%) | -4 |
| Specific Surface Area (m2/g) | -7 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer |
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