This product is a Farage-Luc2 B cell engineering tool based on the Microbubbles (Transferrin/Transferrin receptor) delivery system and CRISPR-based (SHS-255-crRNA:tracrRNA duplex-NLS-Cas9-RS-1) genome editor.
| Host Cell | Farage-Luc2 |
| Target | Thomsen-Friedenreich |
| Insert Clone | JAA-Fl 71L (H2IL2I) |
| Safe Harbor Sites (SHS) | SHS-255 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Microbubbles |
| Ligand/Receptor | Transferrin/Transferrin receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | ≤24100 |
| Charge (mv) | ≤71 |
| Total Atom Count | -73000000 |
| Surface Atoms (%) | -0.6 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer |
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