Name: Recombinant Human Anti-SIRPα x Anti-MUC1 Bispecific Antibody (Tandem scFv)
SKU: KN-1025-N32
Rating: 5 (1 reviews)

Recombinant Anti-SIRPα x Anti-MUC1 Bispecific Antibody (Tandem scFv) is designed to be expressed as a scFv from an anti-SIRPα antibody variable domains fused with a scFv from an anti-MUC1 antibody variable domains. It contains a His-tag at the C/N terminus for affinity purification. The BsAb exits as monomer in reducing and non-reducing conditions. This BsAb can retarget macrophages to MUC1+ tumor cells. It is designed for the research of Pancreatic cancer; Ovarian cancer; Breast cancer; Bile duct cancer (BDC) therapy.

Datasheet INQUIRY

Specifications

Targets

SIRPα & MUC1

Type

Tandem scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Pancreatic cancer; Ovarian cancer; Breast cancer; Bile duct cancer (BDC)

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

SIRPα

Gene ID

140885

UniProt ID

P78324

Alternative Names

SHPS-1; CD172A; p84; MYD-1; BIT; PTPNS1; SIRPA; signal regulatory protein alpha; MFR; P84; MYD1; SIRP; SHPS1; Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; Brain Ig-like molecule with tyrosine-based activation motifs; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3

Target 2

MUC1

Gene ID

4582

UniProt ID

P15941

Alternative Names

MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; Medullary cystic kidney disease, autosomal dominant

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

Online Inquiry

See other bsAb targets related to "MUC1"

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Recombinant Human Anti-SIRPα x Anti-MUC1 Bispecific Antibody (Tandem scFv) (CAT#: KN-1025-N32)

Specifications

Targets

Customer Reviews and Q&As