| CAT# | Product Name | Species Reactivity | BsAb Type | Target 1 | Host Animal 1 | Target 2 | Host Animal 2 | INQUIRY |
|---|---|---|---|---|---|---|---|---|
| KN-0825-N41 | Recombinant Human Anti-MSLN x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) | Human | Fab-scFv/sdAb-Fc | MSLN | Human | 4-1BB | Human | Inquiry |
| KN-0825-N12 | Recombinant Human Anti-MSLN x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) | Human | IgG-scFv | MSLN | Human | 4-1BB | Human | Inquiry |
| KN-1022-LN2 | Recombinant Anti-MSLN x Anti-CD47 Bispecific Antibody (Common heavy chain) (BsIgG) | Human | BsIgG | MSLN | Human | CD47 | Human | Inquiry |
Mesothelin (MSLN) is a 303 aa GPI-anchored protein with a molecule weight of 40 kDa. MSLN creates soluble mesothelin-related peptides (SMRP), which have been employed as markers to detect malignant mesotheliomas. Mesothelin participates in multiple signaling pathways via interactions with soluble MSLN and CA125/MUC16 or by overexpression, to activate Akt, ERK 1/2, JNK, SGK3/FOXO3, p38, NF-κB, and STAT3 pathways, thus regulating the downstream effects like inhibition of Bim, Bad&Bax, and DKK1, or activation of MMP-7, IL6, and Cyclin E/CDK2. These signaling pathways are involved in a wide range of biological activities such as cellular invasion, cellular migration, cell survival, and cellular proliferation, and are closely related to many cancers, making MSLN a notable immunotherapeutic target awaiting investigation.
Fig.1 Signaling pathways associated with mesothelin.1
Reference
Welcome! For price inquiries, we will get back to you as soon as possible.
INQUIRY
SERVICES
PRODUCTS
PLATFORMS
